Biophysical Chemistry

Research Group of Karin Hauser

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Publications

2017

Popp, A.#, Scheerer, D.#, Heck, B., Hauser, K. "Biomolecular dynamics studied with IR-spectroscopy using quantum cascade lasers combined with nanosecond perturbation techniques" Spectrochim. Acta A, 2017, 181, 192–199 [pdf]

Keiderling, T.A., Chi, H., McElheny, D., Walker, A., Scheerer, D.,  Hauser, K. "Three-Strand β-Sheet Peptide Models. IR, VCD and ECD Spectra, T-Jump Dynamics and NMR Structures Support MD and DFT Simulations" Biophys. J. Suppl., 2017, 112, 195a [pdf]

2016

Henke, K., Welte, W., Hauser, K. "Direct monitoring of β-sheet formation in the outer membrane protein TtoA assisted by TtOmp85" Biochemistry, 2016, 55, 4333–4343 [pdf] 

                  Editors' Pick in World Biomedical Frontiers because of its innovation and potential for significant impact

Fallah, M.A.#, Stanglmair, C.#, Pacholski, C., Hauser, K. "Devising self-assembled-monolayers for surface-enhanced infrared spectroscopy of pH-driven poly-L-lysine conformational changes" Langmuir, 2016, 32, 7356–7364 [pdf]

Jawurek, M., Glaubitz, C., Hauser, K. "Impact of the lipid environment on the protonation dynamics of bacteriorhodopsin studied with time-resolved step-scan FTIR spectroscopy" Biomed. Spectros. and Imaging, 2016, 5, 167-174 [pdf]

Popp, A., Scheerer, D., Chi, H., Keiderling, T.A., Hauser, K. "Site-specific dynamics of β-sheet peptides with DPro-Gly turns probed by laser-excited temperature-jump infrared spectroscopy" ChemPhysChem, 2016, 17, 1273-1280 [pdf]

2015

Farhadi Khouzani, M., Chevrier, D.M., Güttlein, P., Hauser, K., Zhang, P., Hedin, N.,  Gebauer, D. "Disordered amorphous calcium carbonate from direct precipitation" CrystEngComm, 2015, 17, 4842-4849 [pdf]

Yushchenko, T., Schloemer, R., Deuerling, E., Hauser, K. "Molecular processes of polyQ protein aggregation studied with time-resolved ATR-FTIR spectroscopy" Eur. Biophys. J. Suppl.1, 2015, 44, 159 [pdf]

Henke, K. Odermatt, M., Welte, W., Hauser, K. "Infrared spectroscopic folding studies of outer membrane proteins" Eur. Biophys. J. Suppl.1, 2015, 44, 155 [pdf]

Donten, M.L., Hassan, S., Popp, A., Halter, J., Hauser, K., Hamm, P. "pH-jump induced leucine zipper folding beyond the di ffusion limit" J. Phys. Chem. B, 2015, 119, 1425–1432 [pdf]

2014

Popp, A., Wu, L., Keiderling, T.A., Hauser, K. "Effect of Hydrophobic Interactions on the Folding Mechanism of β-hairpins" J. Phys. Chem. B, 2014, 118, 14234–14242 [pdf]

Robotta, M., Gerding, H.R., Vogel, A., Hauser, K., Schildknecht, S. Karreman, C., Leist, M, Subramaniam, V., Drescher, M. "Alpha-Synuclein binds to the inner membrane of mitochondria in an alpha-helical conformation“ ChemBioChem, 2014, 15, 2499-2502 [pdf]

Henke, K., Odermatt, M., Welte, W., Hauser, K. "Stability of the Thermus thermophilus outer membrane protein TtoA against heat and denaturants" Biomed. Spectrosc. and Imaging, 2014, 3, 51-56 [pdf]

Popp, A., Wu, L., Keiderling, T.A., Hauser, K. "Time-resolved temperature-jump IR-measurements on ß-hairpin peptides with alternate cross-strand interactions" Biophys. J. Suppl., 2014, 106, 52a [pdf]

Heck, B.S., Doll, F., Hauser, K. "Length-dependent conformational transitions of polyglutamine repeats as molecular origin of fibril initiation" Biophys. Chem., 2014, 185, 47–57 [pdf] 

Deeg, A.A., Rampp, M.S., Popp, A., Pilles, B.M., Schrader, T. E., Moroder, L., Hauser, K., Zinth, W. "Isomerization and Temperature Jump Induced Dynamics of a Photo-Switchable beta-Hairpin" Chem. Eur. J., 2014, 20, 694-703 [pdf]

2013

Heck, B.S., Doll, F., Popp, A., Hauser, K. "Fibril formation of polyglutamine repeats: a spectroscopic study" Eur. Biophys. J. Suppl.1, 2013, 42, 62 [pdf]

Hauser, K. "Infrared-spectroscopy of protein folding, misfolding and aggregation" in: Encyclopedia of Biophysics, G.C.K. Roberts (ed.), ISBN: 978-3-642-16711-9, Springer Berlin-Heidelberg, 2013, vol.2, 1089-1095 [pdf]

2012

Popp, A., Wu, L. Keiderling, T.A., Hauser, K. "Impact of beta-turn sequence on beta-hairpin dynamics studied with infrared detected temperature jump" Spectroscopy, 2012, 27, 557-564 [pdf]

Hauser, K. "Dynamics of alpha-helix and beta-sheet formation studied by laser-induced temperature-jump IR-spectroscopy" book chapter in: "Protein Folding and Misfolding - Shining Light by Infrared Spectroscopy", D. Naumann and H. Fabian (eds.), ISBN 978-3-642-22229-0, Springer Berlin-Heidelberg, 2012, 147-170 [pdf]

2011

Krejtschi, C., Hauser, K. "Stability and Folding Dynamics of Polyglutamic Acid" Eur. Biophys. J., 2011, 40, 673-685 [pdf]

Krejtschi, C., Hauser, K. "Folding rates studied by a combination of static and time-resolved infrared spectroscopy" Eur. Biophys. J. Suppl.1, 2011, 40, 208 [pdf]

2010

Hauser, K., Ridderbusch, O., Roy, A., Hellerbach, A., Huang, R., Keiderling, T.A. "Comparison of isotopic substitution methods for equilibrium and T-jump infrared studies of beta-hairpin peptide conformation" J. Phys. Chem. B, 2010, 114, 11628-11637 [pdf]

Kopitz, A., Soppa, J., Hauser, K. "Analysis of a Hybrid TATA Box Binding Protein Originating from Mesophilic and Thermophilic Donor Organisms" Spectroscopy, 2010, 24, 233-237 [pdf]

2009

Weidemüller, C., Hauser, K. "Ion transport and energy transduction of P-type ATPases: implications from electrostatic calculations" Biochim. Biophys. Acta - Bioenergetics, 2009, 1787, 721-729 [pdf]

Kopitz, A., Soppa, J., Krejtschi, C., Hauser, K. "Differential stability of two TBP proteins from archaea with different optimal growth temperatures" Spectrocimica Acta A - Molecular and Biomolecular Spectroscopy, 2009, 73, 799-804 [pdf]

Krejtschi, C., Ridderbusch, O., Huang, R., Wu, L., Keiderling, T. A., Hauser, K. "Folding dynamics of peptides studied by time-resolved infrared spectroscopy" Eur. Biophys. J. Suppl. 1, 2009, 38, 209 [pdf]

Weidemüller, C., Siu, S., Böckmann, R., Hauser, K. "Ion transport and energy transduction of P-type ATPases studied by simulations " Eur. Biophys. J. Suppl. 1, 2009, 38, 59 [pdf]

Krejtschi, C., Wu, L., Huang, R., Hauser, K., Keiderling, T. A. "Site-specific folding dynamics of isotopically labeled peptides studied by time-resolved infrared-spectroscopy" Biophys. J. Suppl., 2009, 96, 73a [pdf]

2008

Weidemüller, C., Hauser, K.: "A computational approach to study the energy transduction  mechanism in the Na+/K+-ATPase" in: "From Computational Biophysics to System Biology (CBSB08)", U.H.E. Hansmann, J. Meinke, S. Mohanty, W. Nadler, O. Zimmermann (eds.), ISBN 978-3-9810843-6-8, NIC Series, Jülich 2008, 40, 409-411 [pdf]

Weidemüller, C., Hauser, K. "Impact of an electric field on P-type ATPases" Spectroscopy, 2008 22, 319-325 [pdf]

Krejtschi, C., Huang, R., Keiderling, T.A., Hauser, K. "Time-resolved temperature-jump infrared spectroscopy of peptides with well-defined secondary structure: a trpzip beta-hairpin variant as an example" Vibrational Spectroscopy, 2008, 48, 1-7 [pdf]

Hauser, K., Krejtschi, C., Huang, R., Wu, L., Keiderling, T.A. "Site-specific relaxation kinetics of a tryptophan zipper hairpin peptide using temperature-jump IR-spectroscopy and isotopic labeling" J. Am. Chem. Soc., 2008, 130, 2984-2992 [pdf]

Huang, R., Krejtschi, C., Hauser, K., Keiderling, T.A. "TrpZip-based beta hairpin equilibrium and temperature jump IR studies enhanced by site-specific isotope labeling" Biophys. J. Suppl., 2008, 611 [pdf]

Andersson, J., Hauser, K., Karjalainen, E.-L., Barth, A. "Protonation and hydrogen bonding of Ca2+ site residues in the E2P phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase studied by a combination of infrared experiments and electrostatic calculations" Biophys. J., 2008, 94, 600-611 [pdf]

2007

Hauser, K., Barth, A. "Side-chain protonation and mobility in the sarcoplasmic reticulum Ca2+-ATPase: implications for proton countertransport and Ca2+release" Biophys. J., 2007, 93, 1-12 [pdf]

Karjalainen, E.-L., Hauser, K., Barth, A. "Proton paths in the sarcoplasmic Ca2+-ATPase" Biochim. Biophys. Acta - Bioenergetics, 2007, 1767, 1310-1318 [pdf]

Huang, R., Krejtschi, C, Hauser, K., Kim, J., Keiderling, T.A. "Thermal unfolding of a beta hairpin studied with IR spectra enhanced by site-specific isotope labeling" Biophys. J. Suppl., 2007, 92, 208a

2006

Hauser, K. "Electrostatic calculations for assignment of IR difference bands to carboxyl groups getting protonated during protein reactions" Biopolymers, 2006, 82, 430-434 [pdf]

Sukumaran, S., Hauser, K., Maier, E., Benz, R., Mäntele, W. "Tracking the unfolding and refolding pathways of outer membrane protein porin from Paracoccus denitrificans" Biochemistry, 2006, 45, 3972-3980 [pdf]

Sukumaran, S., Hauser, K., Maier, E., Benz, R., Mäntele, W. "Structure-function correlation of outer membrane protein porin from Paracoccus denitrificans" Biopolymers, 2006, 82, 344-348 [pdf]

2005

Sukumaran, S., Hauser, K., Rauscher, A., Mäntele, W. "Thermal stability of outer membrane protein porin from Paracoccus denitrificans: FT-IR as a spectroscopic tool to study lipid-protein interaction" FEBS Letters, 2005, 579, 2546-2550 [pdf]

Andersson, J., Hauser, K., Barth, A. "Protonation of Ca2+-ATPase residues upon Ca2+ release" Journal of General Physiology, 2005, 126 (1), 15A-16A, 35 [pdf]

Hauser, K. "Simulation von Enzymzuständen am Computer - ein Weg zum Verständnis molekularer Details"; G.I.T. Labor Fachzeitschrift, 10/2005, GIT Verlag (Wiley Company) [pdf]

2004

Hauser, K., Mao, J., Gunner, M. "PH dependence of heme electrochemistry in cytochromes investigated by multiconformation continuum electrostatic calculations" Biopolymers, 2004, 74, 51-54 [pdf]

2003

Mao, J., Hauser, K., Gunner, M. "How cytochromes with different folds control heme redox potentials" Biochemistry,2003, 42, 9829-9840 [pdf]

Gunner, M., Mao, J., Hauser, K., Kim, J. "Adding conformational flexibility to continuum electrostatics: Assaying the stability and importance of charges buried in proteins." J. Am Chem Soc., 2003, 225: 116-COMP Part1

Hauser, K., Mao, J., Gunner, M. "PH dependence of heme electrochemistry in cytochromes investigated by multiconformation continuum electrostatic calculations" in:"Spectroscopy of Biological Molecules", ISBN 963 482 614 8, B. Szalontai & Z. Kota (eds.), Szeged 2003, 185

2002

Hauser, K., Engelhard, M., Riesle, J., Oesterhelt, D., Friedman, N., Sheves, M., Siebert, F. "Interpretation of amide I difference bands observed during protein reactions using site-directed isotopically labeled bacteriorhodopsin as a model system" J. Phys. Chem. A, 2002, 106, 3553-3559 [pdf]

Siebert F., Hauser K., Engelhard M., Sheves M., Oesterhelt D. "Interpretation of amide I difference bands observed during protein reactions using site-directed isotopically labeled bacteriorhodopsin as a model system" Biophys. J. Suppl., 2002, 82, 37a-38a [pdf]

1997

Georg, H., Hauser, K., Rödig, C., Weidlich, O., Siebert, F. "Time-resolved infrared spectroscopy of biomolecules" book chapter in: "Biomolecular Structures and Dynamics", G. Vergoten & T. Theophanides (eds.), ISBN 0-7923-2773X, NATO ASI Series E, 342, 1997, 243-261

Hauser, K., Engelhard, M., Siebert, F. "Localisation of structural changes of the alpha-helices during the photoreaction of bacteriorhodopsin by FTIR-difference-spectroscopy of site-directed isotope labelled T46C-BR-mutants" in: "Spectroscopy of Biological Molecules: Modern Trends", P. Carmona, R. Navarro and A. Hernanz (eds.), Kluwer Academic Publishers, Dordrecht, 1997, 111-112

1995

Barth, A., Hauser, K., Mäntele, W., Corrie, J. E. T., Trentham, D. R. "Photochemical release of ATP from "caged ATP" studied by time-resolved infrared spectroscopy" J. Am. Chem. Soc., 1995, 117, 10311-10316 [pdf]